Mons. Mikiel Gonzi was born in Birgu on 13 May 1885 and later when he was five years old, his family moved to Kalkara.

After studying at the Seminary, he was ordained a priest on 19 December 1908. At a time when priests were encouraged to take an active part in the political scene, Fr Mikiel Gonzi became a member of the Labour Party which was just established on 15 May 1921. In 1924, he became the fifth Bishop of Gozo and on 17 December, he became the Bishop of Malta.

He died on 22 January 1984 at the age of 98.