Ġanni Vella was born in Cospicua on 9 May 1885. He started painting at a young age and in 1907, he went to Rome to study at the Accademia di Belle Arti di Roma. He studied also at the British Academy.

On his return from Rome, he produced many religious works which can be found in various churches in the Maltese Islands. Apart from the religious theme, he also painted scenes, illustrated satirical works and designed some stamps.

He passed away on 3 September 1977 aged 92.